Rnf152 rheb
WebRNF152 is an E3 ubiquitin ligase with RING domain and single-pass transmembrane (TM) domain, which is mainly localized in lysosomes . RNF152 exhibits pro-apoptotic activity … WebBioGRID Interaction 2624053 Between RNF152 And RHEB. Toggle navigation. Bio GRID 4.4
Rnf152 rheb
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WebRHEB also known as Ras homolog enriched in brain (RHEB) is a GTP-binding protein that is ubiquitously expressed in humans and other mammals. The protein is largely involved in … WebAug 17, 2024 · The mechanistic target of rapamycin complex 1 (mTORC1) is an essential regulator of cell growth and metabolism through the modulation of protein and lipid …
WebApr 4, 2024 · Objective: To describe a child meeting diagnostic criteria for tuberous sclerosis complex (TSC) carrying a pathogenic somatic variant in RHEB , but no pathogenic variants in the two known TSC genes, TSC1 or TSC2 . Methods: We present the clinical and imaging findings in a child presenting with drug-resistant focal seizures and multiple cortical … http://www.nlm.medscape.idmu.unboundmedicine.unboundmedicine.com/medline/citation/30514904/Ubiquitination_of_Rheb_governs_growth_factor_induced_mTORC1_activation_
WebPlease help us improve further — take a moment to fill our brief user survey. WebRHEB also known as Ras homolog enriched in brain (RHEB) is a GTP-binding protein that is ubiquitously expressed in humans and other mammals. The protein is largely involved in the mTOR pathway and the regulation of the cell cycle.. RHEB is a recently discovered member of the Ras superfamily.Being a relative of Ras, the overexpression of RHEB can be seen in …
WebJan 31, 2012 · Inhibition of Rheb during cellular stress promotes the upregulation of adaptive mechanisms, such as cell cycle arrest and growth inhibition, which may save energy, favor DNA repair, and thus be …
WebMar 4, 2024 · RNF152-deficient mice produce less inflammatory cytokines in response to LPS and are more resistant to LPS-induced lethal endotoxemia. Mechanistically, RNF152 interacts with the adaptor protein MyD88 and enhances oligomerization of MyD88, which is essential for the recruitment of downstream signaling components and activation of … in conclusion japaneseWebFeb 29, 2024 · Therefore, the ubiquitination of Rheb, determined by RNF152 and USP4, also plays an important role in mTORC1 activation and consequent tumorigenesis (Fig. 2a). … im vengeance im the night i\u0027m batmanWebRNF152: E3 ubiquitin-protein ligase RNF152; ... active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. … in conclusion norskWebMar 3, 2012 · Rheb activation increases ATP depletion and ER stress during GD. A, CM ATP content at baseline and after 18 hours of GD was evaluated in CMs with Rheb … in conclusion obesityWebApr 30, 2015 · Deng et al. demonstrate that the lysosome-localized E3 ubiquitin ligase RNF152 negatively regulates mTORC1 function by targeting RagA GTPase for K-63 … im used to callWebDec 1, 2024 · A recent study showed that Lysosome-anchored E3 ligase RNF152 catalyzes Rheb ubiquitination and promotes its binding to the TSC complex, which is of regulatory … in conclusion overallWebJul 5, 2024 · Moreover, the ubiquitination of RHEB regulates its ability to activate mTORC1 . The E3 ubiquitin ligase RNF152 catalyzes RHEB ubiquitination, leading to an increase in … im up and down like a yoyo song