WebDysregulation of several KDMs has also been implicated in diseases including cancer and inflammation [15,20]. The histone methylation states (e.g., ... plant homeodomain finger protein) family and consists of KDM7A (also known as JHDM1D), PHF2 (also known as JHDM1E), and PHF8 (also known as JHDM1F). KDM7A demethylates both H3K9me1/me2 … Web'Simpson-Golabi-Behmelov sindrom , je rijedak nasljedni kongenitalni poremećaj koji može uzrokovati kraniofacijalne, skeletne, vaskularne, srčane i bubrežne abnormalnosti. Postoji visoka prevalencija karcinoma povezana kod osoba sa SGBS, što uključuje Wilmsove tumore, neuroblastom, tumore nadbubrežne žlijezde, jetre, pluća i trbušnih organa.
PHF8 gene: MedlinePlus Genetics
WebFeb 5, 2024 · Go to Variation Viewer for PHF8 variants Summary The protein encoded by this gene is a histone lysine demethylase that preferentially acts on histones in the monomethyl or dimethyl states. The encoded protein requires Fe (2+) ion, 2-oxoglutarate, and oxygen for its catalytic activity. WebThe histone demethylase PHF8 promotes prostate cancer cell growth by activating the oncomiR miR-125b Qiang Ma,* Zhuo Chen,* Guojin Jia, Xueqiang Lu, Xuefeng Xie, Wei Jin Department of Urology, Jinshan Hospital, Fudan University, Shanghai, People’s Republic of China *These authors contributed equally to this workAims: Prostate cancer (PCa) is the … ccs media sustainability
Novel oncogenic roles and regulations of histone demethylase PHF8 …
WebAug 15, 2014 · Herein we report that PHF8 is an oncogenic protein in human non-small cell lung cancer (NSCLC). PHF8 is up-regulated in human NSCLC tissues, and high PHF8 … WebCollectively, our study identified PHF8 as a novel epigenetic factor in hypoxia signaling, and the underlying regulatory mechanisms likely apply to general cancer development involving HIF1α. WebOct 3, 2024 · PHF8 is phosphorylated by CK2, which regulates binding of PHF8 to TopBP1. Importantly, PHF8 regulates TopBP1 protein level by preventing its ubiquitination and degradation mediated by the E3 ligase UBR5. Interestingly, PHF8pS854 is likely to contribute to regulation of TopBP1 stability and DNA replication checkpoint. butcher delivery northern ireland