High metastasis
Web2.1 Cancer cell lines. The 1-LN cell line (a kind gift from Dr. Phillip Walther, Duke University Medical Center) is a highly metastatic cell line derived from the less metastatic PC-3 cell line. The 1-LN cell line expresses high levels of GRP78 on the cell-surface, while PC-3 cells do not express cell-surface GRP78. Web15 mar 2024 · Hepatocellular carcinoma (HCC) is the third leading cause of tumor death worldwide, representing up to 75–85% of all primary liver malignancies, and causes a major global health problem [1, 2].Generally, HCC is often diagnosed at an advanced stage with a high metastasis rate, resulting in the primary cause of mortality [].Thus, elucidation of …
High metastasis
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Web9 dic 2016 · Background and Purpose: No longer considered a single disease entity, breast cancer is being classified into several distinct molecular subtypes based on gene expression profiling. These subtypes appear to carry prognostic implications and have the potential to be incorporated into treatment decisions. In this study, we evaluated patterns of local … Web2 giorni fa · Background: We aimed to investigate the different metastases and prognoses of neuroblastoma (NB) and determine the risk factors of metastasis. Method: Data of 1224 patients with NB were obtained from the Surveillance, Epidemiology and End Results database (2010-2024). Pearson's chi-square test, Kaplan-Meier analysis, multivariable …
Web12 apr 2024 · Ovarian cancer (OC) has the worst prognosis and highest mortality rate among gynecological cancers, causing about 200,000 deaths annually worldwide [].Despite the recent advances in the treatments of OC, the 5-year survival rate of OC remains below 50% owning to its high recurrence and metastasis rate [].Most of the deaths result from … Web8 apr 2024 · High-throughput eccDNA sequencing and bioinformatics analysis were performed to study the distribution pattern and level of eccDNA expression. The …
Web1 ago 2024 · Metastasis is an important factor affecting the prognosis of OS. In studies by Zou et al., OS cells obtained from skip lesions showed stronger metastasis efficiency … Web18 feb 2024 · Secondly the vascularity of normal brain surrounding a metastases is histologically normal, and non-enhancing high T2 signal is due to vasogenic edema. In …
Web10 lug 2024 · Multivariate analysis showed that the risk of hepatic metastasis as first distant metastasis was high in leiomyosarcoma (HR, 4.546; 95% CI, 2.275-9.086) and retroperitoneal onset (HR, 4.588; 95% CI, 2.280-9.231). The 2-year survival rate after hepatic metastasis was 21.7%. Conclusions. The onset of hepatic metastasis indicates …
Web10 nov 2024 · The process by which cancer cells spread to other parts of the body is called metastasis. When observed under a microscope and tested in other ways, … hornby r7337Web7 mag 2024 · The poor prognosis of patients with ovarian cancer is mainly due to cancer progression. γ-Synuclein (SNCG) has reported as a critical player in cancer metastasis. However, its biological roles and mechanism are yet incompletely understood in ovarian cancer, especially in high-grade serous ovarian cancer (HGSOC). This is a retrospective … hornby r7322Web1 apr 2024 · Liver metastases are usually asymptomatic and found during workup of a malignancy. If the hepatic metastatic burden is large, then the presentation or symptoms … hornby r7398WebEpithelial-to-mesenchymal transition (EMT) determines the most lethal features of cancer, metastasis formation and chemoresistance, and therefore represents an attractive target in oncology. However, direct targeting of EMT effector molecules is, in most cases, pharmacologically challenging. Since emerging research has highlighted the distinct … hornby r7305Web27 apr 2024 · Sometimes, bone metastasis causes no signs and symptoms. When it does occur, signs and symptoms of bone metastasis include: Bone pain. Broken bones. Urinary incontinence. Bowel incontinence. Weakness in the legs or arms. High levels of calcium in the blood (hypercalcemia), which can cause nausea, vomiting, constipation and confusion. hornby r7399Web1 mar 2000 · This concept has made the studies on metastasis genes more difficult, because highly metastatic cells are present as a small (or large) population in a primary tumor, based on this concept. If so, we have to find some specific marker to select the cells with high metastatic potential in the primary tumor. hornby r744Web27 nov 2024 · Background Lymph node metastasis (LNM) status is an important prognostic factor that strongly influences the treatment decision of early gastric cancer (EGC). This study aimed to evaluate the pattern and clinical significance of LNM in EGC. Methods A total of 354 patients with carcinoma in situ (n = 42), EGC (n = 312) who underwent radical … hornby r7336