Hepatocellular hypertrophy
Web28 mei 2024 · Hepatocellular hypertrophy was defined as cellular enlargement more than 1.5 times the normal hepatocyte diameter. Inflammation was graded based on the number of inflammatory foci per field... Web1 jan. 2014 · Hepatic enlargement can be due to hepatocellular hypertrophy, hyperplasia, tumours, fatty change, and storage of substances like glycogen. Excessive glycogen in …
Hepatocellular hypertrophy
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WebChemical-induced hepatocellular hypertrophy is frequently observed in rodents, and is mostly caused by the induction of phase I and phase II drug metabolic enzymes and … Web1 apr. 2016 · In PB-treated mice, slight hepatocellular hypertrophy was detected in the centrilobular zone in 4 out of 5 animals at 120 mg/kg/day.In clofibrate-treated mice, slight …
WebThe primary purpose of this chapter is to provide public health officials, physicians, toxicologists, and other interested individuals and groups with an overall perspective on the toxicology of pentachloro-phenol. It contains descriptions and evaluations of toxicological studies and epidemiological investigations and provides conclusions, where possible, on … Web5 jan. 2024 · For example, evaluating hepatocellular and follicular cell hypertrophy in rats, 17, 18 or even in human clinical settings, 19,20 would expect to be benefited by MMO …
WebWhile to a histopathologist the term hepatic hypertrophy is well recognized and readily defined histologically, to a toxicologist, the term can have various connotations including … Web14 apr. 2024 · Hypertrophic cardiomyopathy (HCM) is a genetic cardiac disease that presents with cardiac hypertrophy. HCM phenocopies are clinical conditions that are phenotypically undistinguishable from HCM, but with a different underlying etiology.
Webfoci accompanied by hepatocellular hypertrophy and increased liver weight in mice in an 18-month feeding study for which the NOAEL was 158 mg/kg bw per day, and using a safety factor of 100. There was no available information on the chemical-specific mechanism of action with which to evaluate the relevance of the liver foci to exposure of humans.
Web17 aug. 2024 · Experimental hepatocellular carcinoma treated with dipeptidyl peptidase-4 inhibition, metformin, or anti-PD1 N Polak 1,2 , S Wetzel 1,2 , JM Henderson 1,2 , GW McCaughan 1,2 and MD Gorrell 1,2 1 Centenary Institute and Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia; 2 AW Morrow … beal \\u0026 wilkes pcWebHepatocellular carcinomas, at incidences up to 90%, have been observed in mice fed griseofulvin at maximum concentrations of 3% in the diet for periods of up to 120 weeks. … beal an daingeanWeb1 apr. 2016 · DOI: 10.1016/j.etp.2015.12.005 Corpus ID: 25991264; Histopathological image analysis of chemical-induced hepatocellular hypertrophy in mice. … dgodrtWeb5 jan. 2024 · A and C, Classification as false colored overlay: hepatocellular cytoplasm detected as hypertrophic in cyan, hepatocellular cytoplasm detected as nonhypertrophic … beakys menuWeb13 mei 2010 · Homogeneous eosinophilic hepatocellular cytoplasmic alteration, interpreted as hypertrophy or proliferation of smooth endoplasmic reticulum, was included within … beal \\u0026 bealWebIn many instances, hepatocellular hypertrophy is accompanied by an increase in activity of the hepatic microsomal drug metabolizing enzymes in the absence of any morphological evidence of hepatocellular damage. beal appraisalWeb28 jun. 2010 · Hepatic drug-metabolizing enzyme (DME) induction is an adaptive response associated with changes in preclinical species; this response can include increases in liver weight, hepatocellular hyperplasia and hypertrophy, and … dgoj madrid