WebBackground: Fludarabine, cyclophosphamide, and rituximab (FCR) can improve disease-free survival for younger (age ≤65 years) fit patients with chronic lymphocytic leukaemia with mutated IGHV. However, patients with unmutated IGHV rarely have durable responses. WebMedian PFS was 53.7 months for the FCR arm and 43.2 months for the BR arm (HR, 1.589 [95% CI, 1.25–2.079]; P=0.001). However, the PFS difference was not statistically significant for patients over the age of 65 or in patients with comorbidities, and OS was not significantly different between the two groups. Treatment-related mortality was 3.9 ...
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WebJul 21, 2024 · Atrial fibrillation was rare, 4% of any grade in the acalabrutinib arm and 3% for the A + G arm. Grade 3+ hypertension was also uncommon, 3% or less in all three arms. … WebNov 5, 2024 · Neither of the sudden deaths in the FCR arm had a prior cardiac or hypertensive history or were on cardiac or anti-hypertensive treatment. There were 6 cases of secondary MDS/AML in the FCR arm... pa college of health sciences library
Ibrutinib Plus Rituximab Improves PFS in Previously Untreated …
WebJan 27, 2024 · Well, I’ve made it to the end of the 7-year FLAIR trial in the FCR chemoimmunotherapy arm (treated in 2014/2015) I went to my last review in December … WebMay 18, 2024 · The ibrutinib arm showed an improved PFS and overall survival (OS) versus that seen in the FCR arm [ 11 ]. With a median follow-up of 48 months, the improved PFS with ibrutinib was seen among... WebNov 5, 2024 · FLAIR (ISRCTN01844152) is an ongoing, phase III, multicentre, randomised, controlled, open, parallel group trial for previously untreated CLL requiring therapy … jennie dancing with the stars