WebAug 6, 2024 · The enhanced expression of FBP1 in ovarian cancer cell lines suppressed proliferation and 2-D/3-D invasion, reduced aerobic glycolysis, and sensitized cancer cells … WebFeb 25, 2024 · Fructose 1,6-bisphosphatase (FBPase) is a key enzyme in gluconeogenesis. It is a potential drug target in the treatment of type II diabetes. The protein is also associated with a rare inherited...
miR-193a-3p increases glycolysis under hypoxia by facilitating Akt ...
WebThe aim of the study is to uncover whether fructose-1,6-bisphosphatase 2 (FBP2) is involved in cervical cancer progression via the aerobic glycolysis pathway. FBP2 levels were … WebJan 24, 2024 · Also, 6 phosphofructo-2-kinase/fructose 2,6-bisphosphatase (PFKFB) 3 was shown to be HIF-1 responsive . ... ERBB4 apparently is involved in phosphorylation of PI3K and Akt and promotes proliferation of gastric cancer cells . Decreasing ERBB4 expression by miR-193a-3p reduced Akt activity, ... gloucestershire trading standards service
2203 - Gene ResultFBP1 fructose-bisphosphatase 1 [ (human)]
WebThe bifunctional 6-phosphofructo-2-kinase (EC 2.7.1.105)/fructose-2,6-bisphosphatase (EC 3.1.3.46) ... Blocking this enzyme in prostate cancer cells grown in the lab stalled growth and triggered a catastrophic build-up of free-radicals, suggesting that it could be a suitable drug target. Importantly, this route to energy production is common to ... WebFeb 4, 2013 · PFK-2/FBPase-2 enzymes in hypoxia. Hypoxia is an important component of the tumor microenvironment and can regulate several processes important for tumor … WebJan 18, 2012 · This increases levels of fructose 2,6-bisphosphate which then stimulates phosphofructokinase-1 and glycolysis (figure 2). In muscle, high cAMP (caused by adrenaline release) leads to phosphofructokinase-2 that is active and fructose 2,6-bisphosphatase that is inactive thereby stimulating glycolysis. Figure 1. gloucestershire towns and villages